Immunological Tolerance

Immunological Tolerance PDF
Author: David H. Katz
Publisher: Academic Press
ISBN: 1483273431
Size: 22.92 MB
Format: PDF
Category : Medical
Languages : en
Pages : 660
View: 4800

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Immunological Tolerance: Mechanisms and Potential Therapeutic Applications documents the proceedings of a conference held at Brook Lodge, Michigan, April 27-May 1, 1974. The conference brought together many of the investigators who have actively contributed to furthering knowledge and understanding of immunological tolerance. It will be immediately clear to the reader that the conference was structured in a way to consider phenomena of tolerance and immune suppression as interrelated entities with a certain degree of emphasis on the possible common cellular mechanisms involved. The volume contains 36 contributions presented during the seven sessions of the conference. The papers presented in Session I examined T-cell tolerance. The presentations in Session II focused on B cell tolerance. The papers in Sessions III and IV focused on the mechanisms of B cell and T cell tolerance, respectively. Session V dealt with the activity of suppressor cells as a mechanism of tolerance. The papers in Session VI investigated the suppressive activity of antibody and antigen-antibody complexes. In Session VII a final General Discussion was held in order to identify what has been established concerning the phenomenology and mechanisms of specific immunological tolerance, what are the major unresolved issues, and what approaches appear most promising to answer these questions.

Immunological Tolerance

Immunological Tolerance PDF
Author: Gregory R. Bock
Publisher: John Wiley & Sons
ISBN: 0470515538
Size: 26.30 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 248
View: 4316

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This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.

Immunological Tolerance

Immunological Tolerance PDF
Author: Maurice Landy
Publisher: Academic Press
ISBN: 1483270653
Size: 25.89 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 368
View: 4915

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Immunological Tolerance: A Reassessment of Mechanisms of the Immune Response presents the basic biological phenomena of immunological tolerance. This book discusses immunology as a critical field for the analysis of molecular features of mammalian cell genetics, biosynthesis, differentiation, and interactions among cell types. Organized into six chapters, this book begins with an overview of the relationship between antigen structure and its ability to induce tolerance. This text then examines the essentiality of antigen for the proliferation of activated antibody-forming clones and discusses the role of antibody in homeostasis and suppression. Other chapters consider the restoration and transfer of immunological responsiveness by thoracic duct lymphocytes. This book discusses as well the distribution of antigen in tissues and cells. The final chapter deals with the origin of carrier antibody and the significance of maternal transfer of antibodies and antigens. This book is a valuable resource for immunologists, microbiologists, scientists, and clinicians.

Immune Tolerance Research Developments

Immune Tolerance Research Developments PDF
Author: Emile B. Pontell
Publisher: Nova Publishers
ISBN: 9781604562095
Size: 78.41 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 201
View: 5161

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Immune or immunological tolerance is the process by which the immune system does not attack an antigen. It occurs in three forms: central tolerance, peripheral tolerance and acquired tolerance. Central tolerance is immunological tolerance developed during T and B cell differentiation. Peripheral tolerance is immunological tolerance developed after T and B cells mature and enter the periphery. Acquired or induced tolerance is the immune system's tolerance for external antigens. This book presents the latest research from around the world.

Searching For Immune Tolerance Manipulating New Molecules And Exploiting New Concepts On Lymphocyte Biology

Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology PDF
Author: Karina Pino-Lagos
Publisher: Frontiers Media SA
ISBN: 2889199517
Size: 35.85 MB
Format: PDF, Mobi
Category :
Languages : en
Pages :
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The break on immune tolerance is a common point between autoimmune diseases and the uncontrolled effector immune responses against allo-antigens in transplantation. Among the past years, several approaches to restore a suppressive immune state have included the targeting of co-stimulatory/inhibitory molecules on immune cells, the promotion or blockade of pivotal cytokines, and the extensive study on how to isolate and expand suppressive cells with the purpose to re-infuse them in patients. To date, the availability of new technologies has permitted to learn, in a more detailed way, the immune mechanisms carried out by suppressive lymphocytes, together with the identification of new potential candidates to target in our quest for immune tolerance. For example, the attractive concepts of lymphocyte plasticity and function stability, supported by the finding of new transcription factors, have opened a new window in the understanding of T cell differentiation, effector cell commitment and immune regulatory function. On the other hand, the discovery of new members of the Ig superfamily ligand, VISTA; the intriguing role of modulatory molecules like Retinoic Acid, Neuropilin-1, Fc gamma receptors, or cytokines such as IL-33, among others, are revealing new possibilities in the development of new strategies to conquer our obsession: immune tolerance. Here, we gather the latest information regarding new targets and cellular processes, including an update on current cellular therapies and the exciting coming approaches to cure autoimmunity and permit transplant acceptance.

Mechanisms Of Immunological Tolerance

Mechanisms of Immunological Tolerance PDF
Author: Československá akademie věd. Institute of Experimental Biology and Genetics
Publisher:
ISBN:
Size: 62.74 MB
Format: PDF, ePub, Docs
Category : Immunological tolerance
Languages : en
Pages : 544
View: 3749

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Autoři z 16 zemí přednesli 58 referátů a diskusních příspěvků. Probírali imunologickou toleranci v klasickém smyslu, imunologii a problémy nádorů, stavy tolerance, vzbuzené v dospělých organismech nebo buňkách, toleranci a autoimunitu apod.