Frontiers In Antimicrobial Resistance

Frontiers in Antimicrobial Resistance PDF
Author: David G. White (Ph.D.)
Publisher: Amer Society for Microbiology
ISBN: 9781555813291
Size: 53.99 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 570
View: 2615

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Frontiers in Antimicrobial Resistance: a Tribute to Stuart B. Levy offers a unique examination of the state of antimicrobial and anticancer drug resistance. Written by acknowledged experts who have spent time in Dr. Levy’s laboratory or who have otherwise collaborated with him professionally, this new volume is a tribute to Dr. Levy and acknowledges his significant contributions to the field. Offers a unique scope of coverage, integrating the latest science with public education programs to use antimicrobials appropriately Provides comprehensive and detailed coverage of the most current research on antimicrobial resistance Presents contributions from acknowledged experts in the field Covers the most important clinical pathogens and the major drug classes Addresses an urgent medical crisis Recognizes Dr. Stuart B. Levy and his vital contributions to the field

Genetics Of Acquired Antimicrobial Resistance In Animal And Zoonotic Pathogens

Genetics of Acquired Antimicrobial Resistance in Animal and Zoonotic Pathogens PDF
Author: Axel Cloeckaert
Publisher: Frontiers Media SA
ISBN: 2889453944
Size: 22.92 MB
Format: PDF, Kindle
Category :
Languages : en
Pages :
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Development and spread of antimicrobial resistance is the result of an evolutionary process by which microorganisms adapt to antibiotics through several mechanisms including alteration of drug target by mutation and horizontal transfer of resistance genes. The concomitant occurrence of independent antimicrobial resistance mechanisms is a serious threat to human health and has appeared in several emerging epidemic clones over the past decade in humans and also in animals. The increasing prevalence of antimicrobial drug resistance among animal and zoonotic foodborne pathogens is of particular concern for public health. In this Ebook, we gathered a collection of articles which deal with the most important aspects of the genetics of acquired antimicrobial resistance extending from medically-important resistance, emerging epidemic resistant clones, main mobile genetic elements spreading resistance, resistomes, dissemination between animals and humans, to the “One Health” concept.

Antimicrobial Resistance And Virulence Common Mechanisms

Antimicrobial Resistance and Virulence Common Mechanisms PDF
Author: Etienne Giraud
Publisher: Frontiers Media SA
ISBN: 288945181X
Size: 34.41 MB
Format: PDF, ePub
Category :
Languages : en
Pages :
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Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. It was previously described how mutation-driven or horizontally acquired resistance mechanisms can also have effects on virulence. It was also reported that mobile genetic elements often carry both resistance determinants and virulence-modulating genes, which favors the co-selection of both traits. In the present volume, we present a collection of articles which document additional aspects of the interactions between antimicrobial resistance and virulence in bacteria, and describe their potential therapeutic consequences.

Antibiotic Resistance In Aquatic Systems

Antibiotic Resistance in Aquatic Systems PDF
Author: Satoru Suzuki
Publisher: Frontiers Media SA
ISBN: 2889451313
Size: 75.26 MB
Format: PDF, ePub, Mobi
Category :
Languages : en
Pages :
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Rivers, lakes and the ocean receive antibiotic resistance genes from human environments. The aquatic environments are a huge reservoir and exchange stage of antibiotic resistance genes.

Mechanisms Of Antibiotic Resistance

Mechanisms of antibiotic resistance PDF
Author: Jun Lin
Publisher: Frontiers Media SA
ISBN: 2889195260
Size: 45.31 MB
Format: PDF, ePub, Mobi
Category :
Languages : en
Pages :
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Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

The Antibiotic Era

The Antibiotic Era PDF
Author: Scott H. Podolsky
Publisher: JHU Press
ISBN: 1421415941
Size: 35.90 MB
Format: PDF
Category : Medical
Languages : en
Pages : 328
View: 3899

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In The Antibiotic Era, physician-historian Scott H. Podolsky narrates the far-reaching history of antibiotics, focusing particularly on reform efforts that attempted to fundamentally change how antibiotics are developed and prescribed. This sweeping chronicle reveals the struggles faced by crusading reformers from the 1940s onward as they advocated for a rational therapeutics at the crowded intersection of bugs and drugs, patients and doctors, industry and medical academia, and government and the media. During the post–World War II "wonder drug" revolution, antibiotics were viewed as a panacea for mastering infectious disease. But from the beginning, critics raised concerns about irrational usage and overprescription. The first generation of antibiotic reformers focused on regulating the drug industry. The reforms they set in motion included the adoption of controlled clinical trials as the ultimate arbiters of therapeutic efficacy, the passage of the Kefauver-Harris amendments mandating proof of drug efficacy via well-controlled studies, and the empowering of the Food and Drug Administration to remove inefficacious drugs from the market. Despite such victories, no entity was empowered to rein in physicians who inappropriately prescribed, or overly prescribed, approved drugs. Now, in an era of emerging bugs and receding drugs, discussions of antibiotic resistance focus on the need to develop novel antibiotics and the need for more appropriate prescription practices in the face of pharmaceutical marketing, pressure from patients, and the structural constraints that impede rational delivery of antibiotics worldwide. Concerns about the enduring utility of antibiotics—indeed, about a post-antibiotic era—are widespread, as evidenced by reports from the Centers for Disease Control and Prevention, academia, and popular media alike. Only by understanding the historical forces that have shaped our current situation, Podolsky argues, can we properly understand and frame our choices moving forward.

Frontiers In Medicinal Chemistry Volume 4

Frontiers in Medicinal Chemistry   Volume  4  PDF
Author: Atta-ur Rahman
Publisher: Bentham Science Publishers
ISBN: 1608052079
Size: 16.77 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 882
View: 1557

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""Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, incl"

Advances In Microbial Physiology

Advances in Microbial Physiology PDF
Author:
Publisher: Elsevier
ISBN: 9780080560649
Size: 38.61 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 326
View: 2214

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Advances in Microbial Physiology is one of the most successful and prestigious series from Academic Press, an imprint of Elsevier. It publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work. First published in 1967, the editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to “traditional views of whole cell physiology. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to be an influential and very well reviewed series.

Antibiotic And Chemotherapy E Book

Antibiotic and Chemotherapy E Book PDF
Author: Roger G. Finch
Publisher: Elsevier Health Sciences
ISBN: 0702047651
Size: 23.79 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 916
View: 541

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Well-respected and widely regarded as the most comprehensive text in the field, Antibiotic and Chemotherapy, 9th Edition by Drs. Finch, Greenwood, Whitley, and Norrby, provides globally relevant coverage of all types of antimicrobial agents used in human medicine, including all antiviral, antiprotozoan and anthelminthic agents. Comprehensively updated to include new FDA and EMEA regulations, this edition keeps you current with brand-new information about antiretroviral agents and HIV, superficial and mucocutaneous myscoses and systemic infections, management of the immunocompromised patient, treatment of antimicrobial resistance, plus coverage of new anti-sepsis agents and host/microbe modulators. Reference is easy thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections. Offer the best possible care and information to your patients about the increasing problem of multi-drug resistance and the wide range of new antiviral therapies now available for the treatment of HIV and other viral infections. Stay current with 21 new chapters including the latest information on superficial and mucocutaneous mycoses, systemic infections, anti-retroviral agents, and HIV. Get fresh perspectives and insights thanks to 21 newly-authored and extensively re-written chapters. Easily access information thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections. Apply the latest treatments for anti-microbial organisms such as MRSA, and multi-drug resistant forms of TB, malaria and gonorrhea. Keep up on the latest FDA and EMEA regulations.